Solution for measuring the thickness of drug coatings on cardiac stents Younikon Technology Co., Ltd
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| Background introduction of cardiac stent |
| Coating material for cardiac stent |
| Characteristics of drug coated stents |
| Customer and market situation of cardiac stents |
| Solution for Measuring Coating Thickness of Cardiac Stent |
Background introduction of cardiac stent
Background of Heart Stents
According to the annual mortality rate statistics of human diseases, approximately 17 million people worldwide die from cardiovascular diseases each year, accounting for one-third of the global death toll, with coronary heart disease being the leading cause of death.
Coronary heart disease, also known as ischemic heart disease, is a kind of heart disease caused by coronary atherosclerosis, which causes vascular stenosis or obstruction, coronary circulation disorder, and myocardial ischemia, hypoxia or necrosis.
In 1987, Sigwart applied coronary stent implantation to clinical practice. Subsequently, in the process of interventional development of coronary heart disease, there were two historic leaps: the placement of bare metal stents (BMS) and drug-eluting stents (DES) in the coronary arteries.
The main function of DES is to prevent the occurrence of cardiovascular restenosis and reduce neointimal hyperplasia in the stent during the chronic phase. Drug eluting stents (DES) use a bare metal stent platform to carry (load) anti angiogenic drugs, which are eluted and released locally in the blood vessel, effectively inhibiting stent intimal hyperplasia and preventing stent restenosis. The effective application of drug-eluting stents can reduce the incidence of restenosis and re interventional surgery. It usually consists of three parts: a platform composed of a metal stent, a drug carrier, and a drug.
Coating material for cardiac stent
Cardiac Stent Coating Materials
The common coating materials for cardiac stents are generally the following three types
Inorganic material coated bracket:Including diamond-like carbon (DLC), silicon carbide (SiC), ceramics, carbon molecule coating scaffolds, etc. | Polymer materials:In recent years, the research on vascular stents made entirely of polymer materials has received a lot of attention from researchers and is considered a highly promising material for the production of vascular stents. | protein:Gelatin, 32P colloidal chromium phosphate, plasma, etc. have been reported as carriers for carrying drugs, radioactive substances, or genetically modified organisms, and are only seen in animal experiments. |
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Characteristics of DES drug coated stent
Drug eluting stent characteristics
Characteristics and mechanism of action of DES drug coated stent:
The drug contacts and evenly covers the vascular wall area, using a polymer coating as the carrier and a stent as the drug release platform, carrying a drug dose of<100-200ug. In the coverage area mainly at the steel beam position of the stent coating, the drug release kinetics are slowly and controllably carried out, effectively reducing the occurrence of restenosis.
Drug sustained release characteristics: The combination of drug molecules and sustained release polymer coating materials inhibits scar tissue growth around the stent, effectively reducing the incidence of restenosis in patients.
Anti rejection characteristics: reduce the immune rejection phenomenon in the patient's body, improve the effectiveness of treatment, and enhance the patient's overall recovery experience throughout the course of the disease.
Customer and market situation of cardiac stents
Cardiac stent customers and market
Minimally Invasive Medical, Lepu Medical, Jiwei Medical, Seno Medical, Kangdelai Medical and other companies will be listed one after another. In the next two years, cardiovascular companies such as Huitai, Xintong, and Bomai will also be listed one after another. There will be more than ten listed companies in the cardiovascular field, and funds will continue to gather towards top enterprises.
With the development of China's medical device industry, the Pearl River Delta, dominated by Guangdong's import and export of medical devices, the Yangtze River Delta, with Jiangsu Province having the largest number of registered medical device products, and Beijing, Tianjin, Liaoning, Shandong, which belong to the Beijing Tianjin Bohai Bay region, have become the three important gathering areas of China's medical device industry.
Leading clients in the industry, such as Sino and Kangdelai, focus on product application research and development, driving the demand for product quality testing from other clients in the industry. They radiate to the medical device testing system related units of medical device testing centers in the entire industry, such as Tianjin and Suzhou, and have different requirements for the testing of stents and stent related medical system film layers.
Solution for Measuring Coating Thickness of Cardiac Stent
Measurement of Stent Coating Thickness
Due to the thickness and uniformity of the drug loaded polymer coating, it will affect the release speed and duration of the drug, as well as the coverage of the drug on the surface of the lesion site. Therefore, efficient and accurate measurement of surface coatings is required.
The commonly used measurement methods for the thickness and surface distribution of drug coatings at present are: 1Roughly calculate the thickness of drug coating by controlling the spraying frequency and time. 2Measure film thickness and confirm distribution using a scanning electron microscope ruler. The preparation of samples using the above two methods is relatively complex and the measurement efficiency is low. 3. Using Filmetrics optical thin film measuring instrument It can achieve rapid measurement of film thickness and optical constants. By analyzing the reflection spectra between the upper and lower interfaces of the tested film layer, the measurement results can be obtained within a few seconds.A unique measurement system that automatically measures the thickness of the entire support surface by simply rotating the support during measurement. High efficiency and fast speed. |
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When measurement needs to be carried out in certain small specific areas on the surface of the sample to be tested, or when other applications require a light spot as small as 1 micron, F40 can obtain accurate thickness and optical parameter values by gradually correcting each objective lens and then measuring. |
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Light of different wavelengths will be reflected at the top and bottom of the film, and the total reflected light amount is the superposition of these two parts of reflected light. Due to the wave nature of light, these two parts of reflected light may interfere with constructive interference (intensity addition) or destructive interference (intensity subtraction), depending on their phase relationship. The phase relationship depends on the optical path difference between these two parts of the reflected light, which is determined by the thickness of the film, the optical constant, and the wavelength of the light. When the phase difference is an integer multiple of the wavelength. Generate constructive superposition, where the reflectivity is at its maximum; When the phase difference is half a wavelength, destructive superposition occurs, resulting in reflectivity; The superposition between integer multiples and half wavelength results in an interference pattern with a reflectivity between the maximum and minimum reflections. |
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Installation of equipment and actual testing data
| Sales Manager of Huabei North Region With nearly 10 years of industry background in scientific research and analysis instruments, focusing on applications related to thin film properties and morphology. Through professional and friendly communication, we aim to explore and understand the actual applications and needs of our clients, and provide accurate solutions, serving major research institutes and enterprises in the north for a long time.
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